Factors Associated with Young Mothers Giving Birth to Children with Down Syndrome in Western Libya: A Comparative Epidemiological Study
DOI:
https://doi.org/10.61952/jlabw.v1i4.320Keywords:
Down syndrome, Trisomy 21, Maternal age, Genetic factors, Environmental influences, Public health, LibyaAbstract
This study investigates the relationship between maternal age and other associated factors with the incidence of Down syndrome (Trisomy 21) among live births in Libya. A descriptive-analytical approach was employed, using hospital records and statistical analysis to compare prevalence rates locally, regionally, and globally. The findings revealed that Libya records the highest prevalence, with approximately one case per 516 live births, compared to one case per 600 in the Arab world and one case per 700 globally. While advanced maternal age remains a significant risk factor, the study highlights the role of genetic predisposition, environmental influences, and socio-economic conditions in shaping the incidence of Down syndrome. These results emphasize the urgent need for strengthening prenatal screening programs, improving maternal nutrition, and integrating genetic counseling into healthcare services. The study contributes to the scientific understanding of Down syndrome in the Libyan context and provides evidence-based recommendations for health policy and practice.
References
Haddar, A. (2017). Genetic factors associated with Down syndrome in Libya. Tripoli: University of Tripoli Press.
Hitayezu, J., Niyonzima, P., & Uwimana, C. (2020). Environmental and nutritional factors influencing Down syndrome incidence in Rwanda. African Journal of Public Health, 12(2), 88–97.
King Saud University for Health Sciences (KSAU-HS). (2023). Awareness and screening programs for Down syndrome in Saudi Arabia. Riyadh: KSAU-HS Research Center.
Saleman, A. A., Souliman, S. I., & Suliman, A. I. (n.d.). Relationship of maternal age and some other associated factors to Down syndrome (Trisomy 21). [Unpublished manuscript].
Song, L., Zhang, Y., & Chen, H. (2022). Maternal age and nondisjunction errors: Evidence from Chinese population studies. Journal of Genetics and Medicine, 14(3), 215–223.
Tawfik, M. (2024). Prevalence of Down syndrome among young mothers in Iraq. Baghdad: Al-Mustansiriya University Publications.
Tobruk University Journal of Medical Sciences (TUJMS). (n.d.). Medical research contributions on genetic and pediatric disorders in Eastern Libya. Tobruk: University of Tobruk.
Verma, I. C., Mathews, A. R., Faquih, A., El-Zouki, A. A., Malik, G. R., & Mohammed, F. (1990). Cytogenetic analysis of Down syndrome in Libya. Indian Journal of Pediatrics, 57(2), 235–240.
World Population Review. (2025). Down syndrome prevalence rates by country. Retrieved from https://worldpopulationreview.com
Fezzan University Research Center. (n.d.). Scientific studies and consulting reports on community health and genetic disorders in Southern Libya. Traghen: University of Fezzan.
