The variation in hematological parameters and their association with HbA1c among Type 2 Diabetes Mellitus Patients
DOI:
https://doi.org/10.61952/jlabw.v1i3.214Keywords:
Diabetes, Type 2 Diabetes Mellitus, glycated hemoglobin A1c (HbA1c),, hematological parameters, anemiaAbstract
Variation in the hematological parameters and the onset of anemia are one of the common blood disorders seen in diabetic patients that can exacerbate their complications. This problem has not received sufficient attention to study how common it is and how to treat it among diabetes mellitus (DM) patients. This retrospective study aims to assess the variation of the hematological parameters and their association with HbA1c levels among T2 DM patients in comparison with a healthy control group.
155 patients with T2DM attending diabetes clinics, and 145 healthy subjects were included in this study. Blood samples were collected from both groups. The HbA1c was detected by the HLC-7223GX Tosoh Automated Glycohemoglobin Analyzer, and the hematological parameters were detected by the auto-analyzer Sysmex XN-350 system. The results showed a significant difference between the mean HbA1c level of the two groups, there was a positive correlation between the mean RBCs, WBCs, and Plts count as well as Hb concentration and Hct of the patients and the mean of HbA1c level, while there was a negative correlation between the RBC indices MCV, MCH, and MCHC of the patients and the mean of HbA1c level, the variation was not associated with sex, there was no significant differences between the variation and the HbA1c level increase. We concluded that HbA1c level and hematological parameters had clinical usefulness as surrogate markers for a diagnostic point of view, and possibly a benefit for subjects at increased risk of developing micro / macro vascular complications.
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